Computer simulation is a powerful tool for planning real evacuation scenarios during a crisis. In such context, emotion is a major factor that influences human decision making process and behavior. In this paper, we present our multi-agent simulation through the mathematical formalization of its main components: emotion and its dynamics, an heuristics for evasive actions of agents, the scenarios for tests and the results of theses tests. We show that on one hand, emotions increase the chaos of simulation which leads to an increase of collisions between agents, and on the other hand the evacuation time decreases because agents are more hurry to leave the place of the crisis.
In a technology-driven industry, the appropriate vendors/suppliers can effectively contribute to cobusiness development profits. Key component vendors help dynamically drive solution design firms to achieve strong performances, especially when an integrated circuit (IC) component that has technical know-how specifications dominates an electronic solution design. This paper presents a systematic framework to examine the decision process for the selection of wireless fidelity (Wi-Fi) IC vendor alternatives from the business ecosystem aspect in order to review the importance of buyer-supplier synergistic effects. We implement the fuzzy analytic hierarchy process technique which incorporates a vendor’s capability, productivity, and reliability characteristics into a hierarchical structure and deploys decision experts’ judgments along with vague data analysis to solve a real-world problem faced by a leading company specialized in the research and design of wireless networking solutions. The findings indicate the Taiwanese local vendor is the top priority for alternatives selection, and the results contribute significant values to the design firm’s operation management
In this study, graphene-carbon nanotube (CNT) hybrid films were directly synthesized on polycrystalline copper (Cu) substrates by thermal chemical vapor deposition (CVD) method. Graphene films were synthesized on Cu substrate at 1000°C in mixture of gases: argon (Ar), hydrogen (H2), and methane (CH4). Then, carbon nanotubes (CNTs) were grown uniformly on the surface of graphene/Cu films at 750°C in mixture of Ar, H2, and acetylene (C2H2) gases. Ferric salt FeCl3 solution deposited onto the surface of graphene/Cu substrate by spin coating method was used as precursor for the growth of the CNTs. The density and quality of the CNTs on the surface of graphene/Cu films can be controlled by varying the concentration of FeCl3 salt catalyst
A variety of triterpenoid propargyl amides, prepared from the corresponding acids, was used as substrates for the construction of novel triazole-tethered triterpenoid-AZT conjugates via a click chemistry-mediated coupling with azidothymidine (AZT). Thus, nineteen new hybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triterpenoid-AZT hybrids on KB and Hep-G2 tumor cell lines
This article examined the associations between three forms of homosexuality-related stigma (enacted, perceived, and internalized homosexual stigmas) with risky sexual behaviors, and to describe the mechanisms of these associations, among men who have sex with men (MSM) in Hanoi, Vietnam. We used respondent-driven sampling (RDS) to recruit 451 MSM into a cross-sectional study conducted from August 2010 to January 2011. Data were adjusted for recruitment patterns due to the RDS approach; logistic regression and path analyses were performed. Participants were young and single; most had attended at least some college. Nine out of ten participants engaged in sexual behaviors at moderate to high risk levels. Compared to those who had no enacted homosexual stigma, men having low and high levels of enacted homosexual stigma, respectively, were 2.23 times (95 % CI 1.35–3.69) and 2.20 times (95 % CI 1.04–4.76) more likely to engage in high levels of sexual risk behaviors. In addition, there was an indirect effect of perceived homosexual stigma and internalized homosexual stigma on sexual risk behaviors through depression and drug and alcohol use. Our study provides valuable information to our understanding of homosexual stigma in Vietnam, highlighting the need for provision of coping skills against stigma to the gay community and addressing drinking and drug use among MSM, to improve the current HIV prevention interventions in Vietnam.
The rapid and successful development of the research on graphene and graphene-based nanostructures has been substantially enlarged to include many other two-dimensional hexagonal semiconductors (THS): phosphorene, silicene, germanene, hexagonal boron nitride (h-BN) and transition metal dichalcogenides (TMDCs) such as MoS2, MoSe2, WS2, WSe2 as well as the van der Waals heterostructures of various THSs (including graphene). The present article is a review of recent works on THSs beyond graphene and van der Waals heterostructures composed of different pairs of all THSs. One among the priorities of new THSs compared to graphene is the presence of a non-vanishing energy bandgap which opened up the ability to fabricate a large number of electronic, optoelectronic and photonic devices on the basis of these new materials and their van der Waals heterostructures. Moreover, a significant progress in the research on TMDCs was the discovery of valley degree of freedom. The results of research on valley degree of freedom and the development of a new technology based on valley degree of freedom-valleytronics are also presented. Thus the scientific contents of the basic research and practical applications os THSs are very rich and extremely promising.
Deltex-3-like (DTX3L), an E3 ligase, is a member of the Deltex (DTX) family and is also called B-lymphoma and BAL-associated protein (BBAP). Previously, we established RFP/RET-transgenic mice, in which systemic hyperpigmented skin, benign melanocytic tumor(s) and melanoma(s) develop stepwise. Here we showed that levels of Dtx3l/DTX3L in spontaneous melanoma in RFP/RET-transgenic mice and human melanoma cell lines were significantly higher than those in benign melanocytic cells and primarily cultured normal human epithelial melanocytes, respectively. Immunohistochemical analysis of human tissues showed that more than 80% of the melanomas highly expressed DTX3L. Activity of FAK/PI3K/AKT signaling, but not that of MEK/ERK signaling, was decreased in Dtx3l/DTX3L-depleted murine and human melanoma cells. In summary, we demonstrated not only increased DTX3L level in melanoma cells but also DTX3L-mediated regulation of invasion and metastasis in melanoma through FAK/PI3K/AKT but not MEK/ERK signaling. Our analysis in human BRAFV600E inhibitorresistant melanoma cells showed about 80% decreased invasion in the DTX3L-depleted cells compared to that in the DTX3L-intact cells. Thus, DTX3L is clinically a potential therapeutic target as well as a potential biomarker for melanoma.